Product Science

Scientific literature supporting the anti LPS activity of Protectyn^®

• Bioactive Immune Components of Anti-Diarrheagenic Enterotoxigenic Escherichia coli Hyperimmune Bovine Colostrum Products

• Hutton et al. Bovine antibodies targeting primary and recurrent Clostridium difficle disease are potent antibiotic alternative. Scientific Reports 2017;7: 3665

• Otto W, Najnigier B, Stelmasiak T and Robins-Browne RM. Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteers. Scandinavian J Gastro. 2011;46:862-868

• Quigley EM, Stanton C and Murphy EF. The gut microbiota and the liver. Pathophysiological and clinical implications. J Hepatol. 2013;58: 1020-1027

• Mizrahi M and Ilan Y. The gut mucosa as a site for induction of regulatory T-cells. Curr Pharm Des. 2009; 15: 1-12

• Frazier TH, DiBaise JK and McClain CJ. Gut microbiota, intestinal permeability, obesity-induced inflammation and liver injury. J Parenter Enteral Nutr. 2011; 35:14S

• Rescigno M. The intestinal epithelial barrier in the control of homeostasis and immunity. Trends Immunol. 2011; 32(6): 256-264

• Bringiotti R, Ierardi E, Lovero R, Losurdo G, Di Leo A, Principi M. Intestinal microbiota: The explosive mixture at the origin of inflammatory bowel disease? World J Gastrointest Pathophysiol. 2014 Nov 15;5(4):550-9.

• Grace E, Shaw C, Whelan K and Andreyez HJN. Small intestinal bacterial overgrowth – prevalence, clinical features, current and developing diagnostic tests, and treatment. Aliment Pharmacol Ther. 2013; 38: 674-688

• Ilan Y. Leaky gut and the liver: a role for bacterial translocation in non-alcoholic steatohepatitis. World J Gastroenterol. 2012; 18(21): 2609-2618

• Pimentel M and Chang C. Inflammation and microflora. Gastroenterol Clin North Am. 2011; 40: 69-85

• Nolan JP. The role of intestinal endotoxin in liver injury: a long and evolving history. Hepatology. 2010; 52(5): 1829-1835

•  Viladomiu M, Hontecillas R, Yuan L, Lu P and Bassaganya-Riera J. Nutritional protective mechanisms against gut inflammation. J Nutr Biochem. 2013; 24:929-939

• Holecek M. Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy–therapeutic perspectives. Metab Brain Dis. 2014; 29: 9-17

• Roh YS and Seki E. Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis. J Gastroenterol Hepatol. 2013; 28(S1): 38-42

• Cesaro C, Tiso A, Del Prete A, Cariello R, Tuccillo C, Cotticelli G, del Vecchio Blanco C and Loguercio C. Gut microbiota and probiotics in chronic liver diseases. Dig Liver Dis. 2011; 43: 431-438

• Dhiman RK. Gut microbiota and hepatic encephalopathy. Metab Brain Dis. 2013; 28: 321-32

• Pakkanen R, Aalto J. Growth factors and antimicrobial factors of bovine colostrum. Int Dairy J. 1997; 7:285–297

• Sun Q, Chen X, Yu J, et al. Immune modulatory function of abundant immune related microRNAs in micro vesicles from bovine colostrum. Protein Cell. 2013; 4:197–210

• Gopal PK, Gill HS. Oligosaccharides and glycoconjugates in bovine milk and colostrum. Br J Nutr. 2000; 84(Suppl 1):S69–S74

• Mizrahi M, Shabat Y, Ben Ya’acov A, Lalazar G, Adar T, Wong V, Muller B, Rawlin G, Ilan Y. Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin: results of a phase I/II clinical trial in NASH. J Inflamm Res. 2012; 5:141-50